Services
Tetrad Discovery provides a bespoke in vitro analytical solution to present key data to address the progress of molecules through the drug discovery/development pathway.
Our services include:
- Experimental design:
In collaboration with our clients we design the most efficient, scientific and cost effective studies to help key decision making. - Histology:
Full array of histological paraffin embedded tissue techniques. Comprehensive service from organ to histological/toxicological readings across all tissues. We catalogue an extensive range of tailored staining methods to support your histological needs including but not limited to H&E, Massons Trichrome, Sirius Red, Safranin-O, Reticulin (silver impregnation), PAS, PAS-D, and Alizarin Red. - Immunohistochemistry:
Bespoke immunohistochemistry protocol development, fully optimised and validated with appropriate controls to meet your project needs. a list of immuno protocols include but not limited to are Alpha-Smooth Muscle Actin (α-SMA), Periostin, Ki-67, Caspase 3, 15-Lipoxygenase (15-LO), Nerve Growth factor (NGF), Pan-Cytokeratin, Cytokeratin-5, Cytokeratin-14, Uteroglobin/CC-10 and Surfactant Proteins A, C and D. - Pharmacokinetic/Pharmacodynamic (PK/PD) support:
Tailored analysis of biological agents including Pharmacokinetics/Pharmacodynamics and the measurement of endogenous and exogenous monoclonal antibodies, therapeutic proteins/peptides. - ELLA:
Automated high performance, ultra-high sensitive single and multi-analyte immunoassays and biomarker screening panels. Full list of analytes can be found here . - Biomarker analysis:
Analysis from all sources of biological samples and non-human species utilising traditional and novel methods including Absorbance, Flourescence, Luminescence, ELISA based assays, SDS-Page electrophoresis, Western Blotting, Immunoprecipitation, Magpix and ELLA analyte immunoassays. - Determination of Anti-Drug antibodies (ADA) and their functional activity:
Tetrad Discovery will develop and optimise custom assays for characterisation of ADA’s. - DiscoverX:
Functional cell-based in-vitro pharmacological profiling services with a variety of endpoints using Path hunter luminescent bioassays. - Cell based assays / Cell culture:
Methods to assess cytotoxicity, cell metabolic pathways, assess small molecules in cell based therapies, experimental design of bespoke cell based assays to screen large molecule drug candidates. - Laboratory report writing:
Tetrad Discovery can take the strain of the report writing element of your company, whether it be Preclinical, biology, pharmacology, in-vitro and in-vivo writing, Tetrad Discovery will facilitate by providing high quality and timely assistance.