We don't just run assays; we partner with you. In close collaboration with your team, we design the most efficient, scientifically robust, and cost-effective studies to drive your critical decision-making and accelerate your milestones.

We are able to partner with a specialist team on our business park to offer a completely integrated pipeline for your preclinical research. We work collaboratively with you to design and plan your in-vivo study, overseeing the process with our partner if needed. Once the in-vivo phase is complete, Tetrad seamlessly takes over to deliver the vital downstream analysis including expert histopathology, PK/PD profiling, and custom plate-based assays to turn your samples into decision-ready data.

We provide a comprehensive suite of paraffin-embedded tissue techniques from organ processing to detailed histological and toxicological readings across all tissue types. Our extensive catalogue of tailored staining methods includes (but is not limited to):

• H&E

• Masson’s Trichrome

• Sirius Red

• Safranin-O

• Reticulin (silver impregnation)

• PAS & PAS-D

• Alizarin Red

We excel in custom IHC protocol development. Every assay is optimised with appropriate controls to meet the exact needs of your project. Our established immuno-protocols encompass a wide range of targets including (but not limited to):

• Alpha-Smooth Muscle Actin (α-SMA)

• Periostin

• Ki-67

• 15-Lipoxygenase (15-LO)

• Nerve Growth Factor (NGF)

• Pan-Cytokeratin, Cytokeratin-5 & Cytokeratin-14

• Uteroglobin/CC-10 & Surfactant Proteins (A, C, and D)

We extract robust biological insights from all sources of in-vitro and preclinical biological samples. Our laboratory utilises a powerful blend of traditional and novel platforms, including:

• Absorbance, Fluorescence, and Luminescence detection

• ELISA-based assays

• SDS-PAGE Electrophoresis & Western Blotting

• Immunoprecipitation

• Magpix multiplexing

For projects demanding ultra-high sensitivity, we utilise the automated ELLA platform. This allows us to run high-performance single and multi-analyte immunoassays and comprehensive biomarker screening panels with exceptional precision all while requiring only minimal sample volumes, preserving your precious or limited materials.

We offer tailored analysis of biological agents to support your Pharmacokinetic and Pharmacodynamic (PK/PD) studies, including the measurement of endogenous and exogenous monoclonal antibodies, and therapeutic proteins/peptides.

Our team designs and executes bespoke cell-based assays to screen large molecule drug candidates and assess small molecules in cell-based therapies.

We deliver precise quantitative data to evaluate how your compounds interact with their biological targets. From confirming target engagement using DiscoverX platforms to tracking downstream cell signalling, we provide full plate-based testing support including the rigorous determination of IC₅₀ and EC₅₀ values to confidently guide your optimisation decisions.

Let us take the strain out of your data reporting. Whether your team requires assistance with pre-clinical biology, pharmacology, in vitro, or in vivo writing, Tetrad Discovery provides high-quality, regulatory-ready reports delivered on time, allowing you to focus on your next breakthrough.