Tetrad Discovery provides a bespoke in vitro analytical solution to present key data to address the progress of molecules through the drug discovery/development pathway.
Our services include:
- Experimental design:
In collaboration with our clients we design the most efficient, scientific and cost effective studies to help key decision making.
- Molecular dynamics:
Computational analysis, simulation and the structural biology of molecular systems to facilitate drug design and compound selection for your drug development programme.
Full array of histological techniques including frozen and paraffin embedded tissue. Comprehensive service from organ to histological/toxicological readings across all tissues. We catalogue an extensive range of tailored staining methods to support your histological needs including but not limited H&E, Massons Trichrome, PAS, Sirius Red, Safranin-O, Reticulin (silver impregnation), Cresyl Fast Violet, Alcian Blue and Alizarin Red.
Bespoke immunohistochemistry protocol development, fully optimised and validated with appropriate controls to meet your project needs.
- Pharmacokinetic/Pharmacodynamic (PK/PD) support:
Tailored analysis of biological agents including Pharmacokinetics/Pharmacodynamics and the measurement of endogenous and exogenous monoclonal antibodies, therapeutic proteins/peptides.
Automated high performance, ultra-high sensitive multi-analyte immunoassays and biomarker screening panels. Full list of analytes can be found here .
- Biomarker analysis:
Analysis from all sources of biological samples and non-human species utilising traditional and novel methods including SDS-Page electrophoresis, Western Blotting, Immunoprecipitation, Magpix and ELLA analyte immunoassays.
- Determination of Anti-Drug antibodies (ADA) and their functional activity:
Tetrad Discovery will develop and optimise custom assays for characterisation of ADA’s.
- Epitope mapping:
Efficient method of accurately identifying and characterising antibody antigen binding kinetics.
Functional cell-based in-vitro pharmacological profiling services with a variety of endpoints using Path hunter luminescent bioassays.
- Cell based assays / Cell culture:
Methods to assess cytotoxicity, cell metabolic pathways, assess small molecules in cell based therapies, experimental design of bespoke cell based assays.
- Laboratory report writing:
Tetrad Discovery can take the strain of the report writing element of your company, whether it be Preclinical, biology, pharmacology, in-vitro and in-vivo writing, Tetrad Discovery will facilitate by providing high quality and timely assistance.
Bespoke assays tailored to your requirements
Quality data using state of the art equipment
Delivery to your timelines